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Compound in red wine, chocolate prevents smallpox virus cousins from replicating

“Resveratrol is a small, natural compound in many plants like grapes, cocoa beans, peanuts and blueberries,” said Shuai Cao, postdoctoral researcher studying the effects of resveratrol on viruses. “Our recent study found that high concentrations of resveratrol — higher than anything you may find in food naturally — prevent poxviruses from replicating in human cells.”

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The Kansas State University researchers recorded resveratrol’s success with vaccinia and collaborated with researchers at the CDC to perform similar experiments with monkeypox, a contagious and deadly virus to humans that has caused periodic disease outbreaks in Africa. Resveratrol had the same effect with monkeypox, which means that it has a good chance of inhibiting all poxviruses, Cao said.

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I remember the following study of Resveratrol’s effects on SARS-CoV-2:

Resveratrol shows potential as SARS-CoV-2 antiviral, study finds

To determine which phase of the viral life cycle resveratrol exerts its effects, they conducted two sets of experiments. In one set, they treated the cells with resveratrol before infection; and in another set, resveratrol was administered to SARS-CoV-2 infected cells. Interestingly, the findings revealed that resveratrol, when applied before infection, was capable of inhibiting the viral replication only by 20%; whereas, post-treatment with resveratrol caused a 98% reduction in viral replication. These findings suggest that resveratrol is more efficacious in the presence of the virus.

To further investigate the mode of action of resveratrol, they incubated the cells with both SARS-CoV-2 and resveratrol at the same time and observed that resveratrol could inhibit viral replication by 64%. These findings suggest that resveratrol may be capable of preventing viral entry into the cells.

Resveratrol Side Effects and Health Hazards <~~can affect how blood pressure, anti-coagulant, and anti-platelet medications work. It can also increase the risk of bleeding during and after surgery.

Resveratrol – Uses, Side Effects, And More <~~can interact with some medications and other supplements.