Tag: Broad Institute

Psychedelic Drugs Are Rushing Towards Approval for Therapy. Here’s What’s Next

Tina Marie (Ms. Cat)

Psychedelic Drugs Are Rushing Towards Approval for Therapy. Here’s What’s Next

Yet one glaring problem remains. Despite promising clinical results, no one knows exactly how psychedelic drugs work in the brain. Examining their actions on brain cells isn’t just an academic curiosity. It could give rise to variants that maintain antidepressant properties without the high. And because hallucinogens substantially alter our perception [management?!] of the world, they could be powerful tools for investigating the neurobiology behind consciousness.

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This year, scientists found another common theme—psychedelics seem to “reset” the brain to a more youthful state, at least in mice. Like humans, mice have an adolescent critical period, during which their brains are highly malleable and can easily rewire neural circuits, but the window closes after adulthood.

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An earlier study showed that MDMA reopens the critical window in adult mice, so that they change their “personality.” Mice raised alone are often introverted and prefer to keep to themselves in adulthood. A dose of MDMA increased their willingness to snuggle with other mice—essentially, they learned to associate socializing with happiness, concluded the study.

It’s not that surprising. MDMA is well-known to promote empathy and bonding. The new study, by the same team, extended their early results to four psychedelics that don’t trigger fuzzy feelings—LSD, ketamine, psilocybin, and ibogaine. Similar to MDMA, adult mice raised alone changed their usual preference for solitude when treated with any of the drugs. Because habits are hard to change in adulthood—for mice and men—the drugs may have reopened the critical period, allowing the brain to more easily rewire neural connections based on new experiences.

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These are just early results. But psychedelic research is gaining a new ally—artificial intelligence. Algorithms that predict protein structure, combined with rational drug design, could generate psychedelics that retain their psychiatric benefits without the high.

H/T: The Most Revolutionary Act

Related:

Psychoanalytic roots of CIA psychoprofiling/pseudoscience

Meaghan thought psychedelic therapy could help her PTSD. Instead it was the start of a nightmare

Why is the American right suddenly so interested in psychedelic drugs

What if a Pill Can Change Your Politics or Religious Beliefs? (archived)

Do Psychedelic Trips Change Your Political Views? (archived)

I Tested Positive for Covid-19. What Does That Really Mean?

Tina Marie (Ms. Cat)

I Tested Positive for Covid-19. What Does That Really Mean?

Michael Mina, an assistant professor of epidemiology at Harvard, believes there should be more focus on the so-called cycle threshold, the number of PCR amplification cycles required to produce a positive result. A high number of cycles suggests a low viral load. This may indicate that someone is at the beginning of an infection—or the end of one. If a person tests positive but is symptom-free, and a subsequent test shows a lower viral load, then they might not need to quarantine for as long. Public health experts increasingly are debating this idea. Some believe that a more nuanced picture could help control the spread of the disease by pinpointing the most infectious people and reducing the burden of quarantine for those who are not infectious. Others warn that the cycle threshold may not be a sufficiently reliable gauge of viral load, since it is influenced by the equipment, the chemistry, and the quality of the sample in each test.