BUT WHY?! Kenya Has Zero Cases But U.S Pharmaceutical Firm To Start Vaccine Trial + WHO Issues Monkeypox Advisory to Kenya

Video via Wongel Zelalem

Tonix will test its monkeypox vaccine in Kenya next year, and no eyes on accelerated path at FDA

The study of Tonix Pharmaceuticals’ live virus vaccine will occur at Kenya Medical Research Institute, or KEMRI, in the East African country, the partners said Thursday. While Kenya has no reported cases of the virus that leads to painful lesions, the country is close to the Democratic Republic of the Congo, which had 163 cases as of July 27, according to a CDC tracker.

Tonix has been working on monkeypox and smallpox for close to a decade, Lederman said. The company’s vaccine, dubbed TNX-801, is traced back to a research collaboration with the Department of Cell Biology at the University of Alberta.

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Compound in red wine, chocolate prevents smallpox virus cousins from replicating

Disclaimer: The information posted here is not a substitute for professional medical advice, diagnosis or treatment. Please seek the advice of a medical professional before taking any supplements!

Compound in red wine, chocolate prevents smallpox virus cousins from replicating

“Resveratrol is a small, natural compound in many plants like grapes, cocoa beans, peanuts and blueberries,” said Shuai Cao, postdoctoral researcher studying the effects of resveratrol on viruses. “Our recent study found that high concentrations of resveratrol — higher than anything you may find in food naturally — prevent poxviruses from replicating in human cells.”

The Kansas State University researchers recorded resveratrol’s success with vaccinia and collaborated with researchers at the CDC to perform similar experiments with monkeypox, a contagious and deadly virus to humans that has caused periodic disease outbreaks in Africa. Resveratrol had the same effect with monkeypox, which means that it has a good chance of inhibiting all poxviruses, Cao said.

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I remember the following study of Resveratrol’s effects on SARS-CoV-2:

Resveratrol shows potential as SARS-CoV-2 antiviral, study finds

To determine which phase of the viral life cycle resveratrol exerts its effects, they conducted two sets of experiments. In one set, they treated the cells with resveratrol before infection; and in another set, resveratrol was administered to SARS-CoV-2 infected cells. Interestingly, the findings revealed that resveratrol, when applied before infection, was capable of inhibiting the viral replication only by 20%; whereas, post-treatment with resveratrol caused a 98% reduction in viral replication. These findings suggest that resveratrol is more efficacious in the presence of the virus.

To further investigate the mode of action of resveratrol, they incubated the cells with both SARS-CoV-2 and resveratrol at the same time and observed that resveratrol could inhibit viral replication by 64%. These findings suggest that resveratrol may be capable of preventing viral entry into the cells.

Resveratrol Side Effects and Health Hazards <~~can affect how blood pressure, anti-coagulant, and anti-platelet medications work. It can also increase the risk of bleeding during and after surgery.

Resveratrol – Uses, Side Effects, And More <~~can interact with some medications and other supplements.

Biden administration weighs declaring monkeypox a health emergency + Break Out the Condoms to Fight Monkeypox

Biden administration weighs declaring monkeypox a health emergency

Related:

Doctors treating monkeypox complain of ‘daunting’ paperwork, obstacles

D.C. shifts monkeypox vaccine policy to focus on first dose

Break Out the Condoms to Fight Monkeypox (archived if you can read behind the advertisements)*

But we should also remember that we have never vaccinated our way out of any pandemic. In the West, measles, scarlet fever, and other childhood diseases stopped killing kids decades before vaccines—our preferred tool of mass salvation—arrived in the late 1950s. Smallpox was similarly largely controlled by the turn of the 20th century through public health measures.

We need to stop subordinating people to the virus. A single approach of surveillance, isolation, contact tracing, and vaccination worked very well for smallpox, which relied exclusively on a human host, could be diagnosed at 10 paces, and was prevented with a single vaccination. But even that approach relied not only on tests and vaccines but also, most of all, on trust—to be tested and vaccinated. Candor is a prerequisite for trust.

*Just a little deception behind the headline. Still touting vaccines (Jynneos), as a solution, though! Just use condoms, for prevention, and prescribe antivirals (TPOXX), for treatment, if needed!

“Immense Frustration”: Monkeypox Spreads Amid Slow U.S. Response, Few Vaccines; WHO Declares Emergency

“Immense Frustration”: Monkeypox Spreads Amid Slow U.S. Response, Few Vaccines; WHO Declares Emergency

But we also know — look, COVID is — you know, a lot of us, by now, have done COVID isolation, 10 days, even five days. It is incredibly difficult. It is costly. Sometimes you miss out on work. Sometimes you have to get a hotel to isolate in. It is really difficult to do. Here we have an isolation with monkeypox that is two to six weeks. That is incredibly disruptive for people’s lives. We’ve been having to crowdfund to get people the money that they need to take time off work. We need emergency funds and hotel rooms so people can properly isolate to prevent the spread. And none of that, none of those funds and resources have been coming from any level of government.

Two to six weeks! 😳