Tag: RNA

The FDA loves horse medicine if it’s really expensive, still under patent, and toxic (Fauci, Baric, Denison, DTRA & Gilead Sciences)

Tina Marie (Ms. Cat)

The FDA loves horse medicine if it’s really expensive, still under patent, and toxic

Related:

Study shows effectiveness of pill form of remdesivir to treat COVID-19 in mice (Ralph Baric & Gilead Sciences)**

Molnupiravir & Ivermectin’s Equine Connections

An emerging antiviral takes aim at COVID-19

[Molnupiravir] EIDD-2801’s story starts years before the coronavirus crisis. In 2014, Painter and his colleagues at Emory University began a project funded by the Defense Threat Reduction Agency to find an antiviral compound that could fight Venezuelan equine encephalitis virus (VEEV). During the Cold War, both the US and the Soviet Union studied VEEV as a potential biological weapon. Typically transmitted through mosquito bites, VEEV causes high fevers, headaches, and sometimes encephalitis, swelling of the brain that can be deadly.

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In late 2019, Painter got a contract from the National Institute of Allergy and Infectious Diseases* to move EIDD-2801 into Phase I clinical trials for influenza. The plan was to file an investigational new drug application and find a partner to help with the clinical work.

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Just as the team was contemplating its next move, word of a virus spreading in Wuhan, China, was starting to make news. One of Painter’s collaborators, UNC coronavirus expert Ralph Baric**, immediately alerted him that the new pathogen was probably a coronavirus—one that EIDD-2801 could potentially combat.

Denison*** says the research team knew a coronavirus outbreak was inevitable. “Every single one of our grants, every single one of our papers predicted that this event was going to happen that’s occurring right now,” he says. “The whole goal of our drug development was to plan for this.”

*Anthony Fauci, director of NIAID.

**Ralph Baric, patents.

***Mark Denison (Denison Lab/Vanderbilt University Medical Center & Gilead Sciences)

I Tested Positive for Covid-19. What Does That Really Mean?

Tina Marie (Ms. Cat)

I Tested Positive for Covid-19. What Does That Really Mean?

Michael Mina, an assistant professor of epidemiology at Harvard, believes there should be more focus on the so-called cycle threshold, the number of PCR amplification cycles required to produce a positive result. A high number of cycles suggests a low viral load. This may indicate that someone is at the beginning of an infection—or the end of one. If a person tests positive but is symptom-free, and a subsequent test shows a lower viral load, then they might not need to quarantine for as long. Public health experts increasingly are debating this idea. Some believe that a more nuanced picture could help control the spread of the disease by pinpointing the most infectious people and reducing the burden of quarantine for those who are not infectious. Others warn that the cycle threshold may not be a sufficiently reliable gauge of viral load, since it is influenced by the equipment, the chemistry, and the quality of the sample in each test.