Alzheimer’s latest drug and science journalism’s memory problem

In July, the medical community was rocked by a disappointing reminder of science’s weakest link: the humans doing the work. The journal Science had shared that its six-month investigation supported the findings of whistleblower Matthew Schrag, who first noted altered images in a high-impact paper on Alzheimer’s, published in Nature in 2006. That paper is still flagged on Nature as under review, but the damage has already been done. Alzheimer’s drugs for the last decade and a half have been developed around claims without as much evidence as initially believed—which might also explain why they haven’t been working, leading people to pour false hope into useless and often expensive treatment plans for declining loved ones.

Alzheimer’s latest drug and science journalism’s memory problem

Brazilian Anarchist expert reveals Social War behind key Lula / Bolsonaro Vote

Brazilian Anarchist expert reveals Social War behind key Lula / Bolsonaro Vote

Despite the glowing picture that progressives and social democrats paint of Lula, it was under the PT (Worker’s Party) that Brazil’s government made its turn toward austerity. Given that this will likely be a second term in office for him, how effective do you think left organizations and movements will be at wringing concessions from a Lula-led PT government?

Compound in red wine, chocolate prevents smallpox virus cousins from replicating

Disclaimer: The information posted here is not a substitute for professional medical advice, diagnosis or treatment. Please seek the advice of a medical professional before taking any supplements!

Compound in red wine, chocolate prevents smallpox virus cousins from replicating

“Resveratrol is a small, natural compound in many plants like grapes, cocoa beans, peanuts and blueberries,” said Shuai Cao, postdoctoral researcher studying the effects of resveratrol on viruses. “Our recent study found that high concentrations of resveratrol — higher than anything you may find in food naturally — prevent poxviruses from replicating in human cells.”

The Kansas State University researchers recorded resveratrol’s success with vaccinia and collaborated with researchers at the CDC to perform similar experiments with monkeypox, a contagious and deadly virus to humans that has caused periodic disease outbreaks in Africa. Resveratrol had the same effect with monkeypox, which means that it has a good chance of inhibiting all poxviruses, Cao said.

Related:

I remember the following study of Resveratrol’s effects on SARS-CoV-2:

Resveratrol shows potential as SARS-CoV-2 antiviral, study finds

To determine which phase of the viral life cycle resveratrol exerts its effects, they conducted two sets of experiments. In one set, they treated the cells with resveratrol before infection; and in another set, resveratrol was administered to SARS-CoV-2 infected cells. Interestingly, the findings revealed that resveratrol, when applied before infection, was capable of inhibiting the viral replication only by 20%; whereas, post-treatment with resveratrol caused a 98% reduction in viral replication. These findings suggest that resveratrol is more efficacious in the presence of the virus.

To further investigate the mode of action of resveratrol, they incubated the cells with both SARS-CoV-2 and resveratrol at the same time and observed that resveratrol could inhibit viral replication by 64%. These findings suggest that resveratrol may be capable of preventing viral entry into the cells.

Resveratrol Side Effects and Health Hazards <~~can affect how blood pressure, anti-coagulant, and anti-platelet medications work. It can also increase the risk of bleeding during and after surgery.

Resveratrol – Uses, Side Effects, And More <~~can interact with some medications and other supplements.

Senate Passes $280 Billion Industrial Policy Bill Meant to Counter China

Senate Passes $280 Billion Industrial Policy Bill Meant to Counter China

The CHIPS and Science Act of 2022 passed in a vote of 63-33, with 17 Republicans voting in favor. The over 1,000-page legislation includes $52.7 billion for direct funding for the construction and expansion of semiconductor manufacturing and $24 billion for tax incentives and other purposes.

The bill will authorize roughly $200 billion in science and technology research funding that will be spread across several government agencies over the next five years. The largest recipient of the research funds will be the National Science Foundation, which will receive $81 billion.

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CHIPS Won’t Help China

Third, the CHIPS Act actually has provisions designed specifically to restrict investments in China. These so-called “guardrails” require that companies taking federal dollars for American projects must also agree not to invest in state-of-the-art technology in China—not just with the federal dollars, with any dollars. Good-faith critics have raised fair concerns that these guardrails should be broader, tougher, and firmer. But any guardrails at all represent unprecedented restrictions on what U.S. companies can do in the People’s Republic. It’s one thing to say an ideal bill would hurt China even more; it’s quite another to try and claim that less-than-perfect restrictions count as “help.”

Pelosi’s Husband Dumped Up to $5M of Tech Stock Right Before Senate Passed CHIPS

Pelosi’s Husband Dumped Up to $5M of Tech Stock Right Before Senate Passed CHIPS

Just before the Senate passed a major bill to subsidize computer chip manufacturers on Wednesday, House Speaker Nancy Pelosi’s (D-California) husband sold thousands of shares of Nvidia — a tech company that could stand to gain from the passage of the nearly $80 billion bill.

Pelosi’s Husband Dumped Up to $5M of Tech Stock Right Before Senate Passed CHIPS

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Nancy Pelosi And Husband Sell NVIDIA Corp Stock After Public Pressure

“I think this comes in response to public pressure and the conflict of interest her stock position posed,” the founder of Congresstrading.com, who asked to remain anonymous due to the sensitive nature of his site, told Benzinga.

“It is surprising to see the sale. Also, what’s surprising here is that she sold and reported one day later. Usually she takes a couple of weeks. She wanted the public to know she cleared her books of this conflict of interest immediately.”

Congresstrading also noted Pelosi’s filings typically come on Fridays, when the media may potentially bury the story over the weekend.

The Nancy Pelosi Tracker on Twitter, which shares transactions by the Speaker of the House, noted the transaction history of NVIDIA Corporation by the Pelosis dates back to May 2021. According to the account, the Pelosis still own 50 options on NVIDIA Corporation with a strike price of $100 and expiration of Sep. 16, 2022 that were purchased back on July 23, 2021.

Pelosi remains one of the most active filers of stock transactions in Congress due to her husband being a venture capitalist.

GT investigates: Who are the mouthpieces of US-led war of public opinion on “Chinese dams’ threats” along Mekong River

GT investigates: Who are the mouthpieces of US-led war of public opinion on “Chinese dams’ threats” along Mekong River, and what are their typical methods? By Hu Yuwei and Zhao Juecheng Mar 28 2022

US’ politicization of ecological water issues in the Mekong River for the purpose of tarnishing China’s reputation via launching rhetoric battles has become more trendy. The Stimson Center, a US-backed think tank, again bashed China in February for allegedly “holding a massive amount of water” and “might need to be paid to release water for downstream communities afflicted by droughts,” marking the US’ latest efforts to sow discord in the area.

GT investigates: Who are the mouthpieces of US-led war of public opinion on “Chinese dams’ threats” along Mekong River

Related:

Mekong-US Partnership: Promoting Poverty, Driving Sinophobic Hostility